IntroductionDual ubiquitination mediated by S-phase kinase-associated protein 2 (SKP2) plays a critical role in breast cancer progression by directing substrates toward either proteasomal degradation or signaling activation. However, the structural determinants governing SKP2 recognition of different ubiquitin-linked substrates, particularly p27 and Akt1, remain poorly understood.MethodsTo invest…
Leveraging AI capabilities combined with genetic data led St. Jude Children's Research Hospital investigators to predict new cancer drug targets that carry a limited risk of side effects.
