Background Hypoxic hepatitis (HH) after on-pump coronary artery bypass grafting (CABG) is associated with poor outcomes, but dedicated prediction tools are lacking. We developed and internally validated a parsimonious model for severe postoperative aminotransferase elevation compatible with HH. Methods This retrospective single-center study included 626 consecutive adults who underwent CABG with cardiopulmonary bypass at Beijing Anzhen Hospital between June 2020 and June 2023. The outcome was pe