FOXP1 promotes the proliferation and self-renewal of spermatogonial stem cells via the nuclear factor kappa B pathway

BACKGROUND The proliferation and self-renewal of spermatogonial stem cells (SSCs) are essential for maintaining the sperm production process. The molecular mechanisms of self-renewal and differentiation of SSCs have not been fully clarified, although the functions of some regulatory factors in SSCs have been previously reported. AIM To investigate the role of forkhead box P1 (FOXP1) in regulating the proliferation and self-renewal of SSCs and its potential mechanism via the nuclear factor kappa