Histological transformation in lung cancer: a single-arm meta-analysis and systematic review
Lefei Hu·Xiaoyong Shen·Chen, Xiaoyu, 1974-·Fuzhi Yang·Shuai Jiang·Shixiang Guo·Ming‐Feng Wei·Zheng Li·Xunxia Zhu
Abstract Background Histological transformation represents an important mechanism of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in EGFR-mutant lung cancer; however, its incidence, timing, and post-transformation outcomes remain incompletely characterized. Methods We conducted a systematic review and meta-analysis in accordance with PRISMA guidelines and Cochrane recommendations. PubMed, Web of Science and Embase were searched up to November 202