A Case Report of Reversible Mitochondrial Bioenergetic Dysfunction in PBMCs in Anti-GAD65–Associated Cerebellar Ataxia
Natália Huňarová·Pavol Skáčik·Milan Grofik·Štefan Sivák·Martin Kolísek·Andrea Izarik Verespejova·Egon Kurča
Abstract Immune-mediated cerebellar ataxias lack dynamic biomarkers that reflect systemic metabolic changes during treatment. In this longitudinal case of anti-GAD65 cerebellar ataxia, high-resolution respirometry of peripheral blood mononuclear cells (PBMCs) revealed treatment-associated shifts in mitochondrial bioenergetic organization that occurred in temporal association with clinical improvement. A 61-year-old woman presented with a 6-month history of progressive gait instability, downbeat