Impaired Iron-Copper Metabolic Axis in Human Intestinal Mucosa After Roux-en-Y Gastric Bypass: A Prospective Transcriptomic Study Using Double-Balloon Enteroscopy
Camila Shimizu·Priscila Sala·Dan Linetzky Waitzberg·Steven B. Heymsfield·Mariana Doce Passadore·Raquel Susana Torrinhas
Abstract Background Roux-en-Y gastric bypass (RYGB) effectively leads to weight loss in patients with severe obesity but is often accompanied by refractory iron deficiency. The molecular mechanisms governing the human intestinal copper-iron metabolic axis post-surgery remain poorly defined. This study evaluated the longitudinal impact of RYGB on intestinal gene expression related to micronutrient homeostasis. Methods In a prospective study of 20 women (body mass index, BMI 46.5 ± 5.3 kg/m²), int