Digital DNA Nanostructures for Ultrasensitive Multiplexed Heavy Metal Sensing via Nanopore Platforms
Zi Wang·Kaikai Chen·Chengwei Luo·Y T Li·Zhongfei Liu·Y C Zhu·Fei Zheng·刘业翔·Yanrong Chen·Yingzhuang Ma·Qing Zhao·Rui Hu
ABSTRACT Heavy metal contamination in freshwater ecosystems represents a persistent global health crisis, yet scalable monitoring is hindered by the trade‐off between sensitivity and multiplexing capability in current sensors. Here, we overcome this limitation by developing a single‐molecule nanopore platform that integrates digitally encoded DNAzyme probes for simultaneous, ultrasensitive quantification of diverse metal ions. Our design features programmable DNAzyme probes that translate specif