Integrated clinicopathological model versus TNM for predicting survival in resected hepatocellular carcinoma: a retrospective cohort study

Abstract Objective To explore prognostic factors of postoperative hepatocellular carcinoma (HCC) and compare the prognostic performance of the tumor–node–metastasis (TNM) system with an integrated clinicopathological model. Methods We conducted a cohort study evaluating 249 patients with HCC who underwent radical liver resection between January 2015 and December 2024. Overall survival (OS) was the primary endpoint. Independent prognostic factors were determined using the Cox proportional hazards