Twenty-four-hour blood pressure and CSF biomarkers of Alzheimer’s disease and related dementias in a community cohort
Madeline Gibson·Matthew P. Pase·Ella Rowsthorn·Katherine H. Franks·Lachlan Cribb·Marina Cavuoto·Beaudan Campbell-Brown·Ian Harding·Meng Law·Trevor T.-J. Chong·Stuart J. McDonald·Terence J. O’Brien·Lucy Vivash·Stephanie Yiallourou·William T. O’Brien
Abstract Hypertension in midlife is associated with increased dementia risk, yet its relationship with early pathological changes of Alzheimer’s disease and related dementias (ADRD) remains unclear. Unlike office blood pressure (BP), 24-h ambulatory BP (ABPM) may better reflect cardiovascular risk, but associations between 24-h BP measures with ADRD biomarkers are unknown. This cross-sectional study examined associations between BP and cerebrospinal fluid biomarkers of ADRD in mid-to-late life.