3D-Printed Polylactide-Based Implants: Influence of Processing, Radiation Sterilization and In Vivo Bioresorption on Structural and Physicochemical Material Characteristics
Monika Dobrzyńska‐Mizera·Maria Laura Di Lorenzo·Małgorzata Muzalewska·Marek Wyleżoł·Jacek Andrzejewski·Patryk Mietliński·Bartosz Gapiński·Maciej Stagraczyński·Michał Mikulski·Alessandra Longo·Giovanni Dal Poggetto·Maria Cristina Del Barone·Monika Knitter
The manuscript details the influence of high-temperature and high-shear processing, as well as radiation sterilization, on properties of bioresorbable and osteoconductive, patient-tailored alloplastic scaffolds for guided bone regeneration. Functionalized poly(l-lactide-co-d,l-lactide) copolymer filled with hydroxyapatite was used to produce two personalized implants for upper and lower jaw reconstruction via 3D printing. Morphology analysis (SEM, µCT), gel permeation chromatography, and thermal