Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer’s disease biomarkers
Hanna Boscheck·DELCODE study group·Selin Senguel·Peter Dechent·Boris Rauchmann·Sebastian Sodenkamp·Eike Spruth·Sophia Stoecklein·Gabriel Ziegler·Frederic Brosseron·Maxie Luft·Ylenia D’elia·Klaus Fliessbach·Wenzel Glanz·Stefan Hetzer·Daniel Janowitz·Ingo Kilimann·Luca Kleineidam·Marie Kronmüller·Falk Lüsebrink·Lukas Preis·Ayda Rostamzadeh·Björn Hendrik Schott·Renat Yakupov·R Perneczky·J Priller·Alfredo Ramirez·A Spottke·Jens Wiltfang·E Düzel·M Wagner·Natalie L. Marchant·Miranka Wirth·Katharina Buerger·Julian Hellmann-Regen·C Laske·O Peters·Anja Schneider·Stefan Teipel·F Jessen·Sandra Röske·Franka Glöckner·Olga Klimecki·René Mauer
Potentially modifiable lifestyle and psychological factors may influence Alzheimer’s disease (AD)-related brain pathology and cognitive function, thereby influencing cognitive resilience in late life. This cross-sectional study investigated associations and pathways between lifestyle and psychological factors related to cognitive reserve and psychological debt, AD-related biomarkers, and cognitive function, as well as potential differences in these associations between AD risk groups. In total,