Multicomponent Lipid Nanoparticles as a Tool to Potentially Improve the Antibiofilm Activity of Resveratrol against MDR Gram-Positive and Gram-Negative Clinical Isolates

Background: Among natural compounds suggested as antimicrobials to overcome the increasing phenomenon of multidrug resistance (MDR), resveratrol (3,5,4′-trihydroxystilbene; RSV), a phytoalexin commonly found in food and drinks, can be considered a valid alternative. Despite its potentially useful antimicrobial action, orally administered RSV fails in efficacy due to several drawbacks (e.g., first pass effect metabolism, instability, poor water solubility), whereas targeted administration could p