A Nanozyme-Loaded pH/Reactive Oxygen Species-Responsive Injectable Hyaluronic Acid/Gelatin Conductive Hydrogel for Coordinated Anti-Inflammation and Angiogenesis in Wound Healing

Complex wounds remain a clinical challenge due to their multifaceted pathophysiology, which involves persistent inflammation, oxidative stress, tissue hypoxia, and impaired angiogenesis. To address these issues, we developed an injectable, self-healing, and conductive hydrogel based on a dual dynamic covalent network formed by cross-linking phenylboronic acid-modified oxidized hyaluronic acid (OHA-PBA) and dopamine-grafted gelatin (GelDA). This network mimics the native extracellular matrix with