Eu3+ Complex-Protein Co-Crystals as Smart Sensors of Biologically Relevant Cations in Blood
Miao Qiu·Jianguo Tang·Runnian Han·Yao Wang·Wei Wang·Yanxin Wang·Jun Li·Christopher Snow·Matt J. Kipper·S W Lee·Laurence A. Belfiore·Min Zhang
This study aimed to develop a novel fluorescent sensor based on Eu3+ complex-doped protein crystal (EC-PC) for the efficient detection of metal ions in blood. By meticulously controlling the crystallization and annealing conditions in the co-crystallization strategy, the crystal growth processes were optimized to obtain doped Eu3+ complex-co-protein crystalline (EC-PC) structures. Thus, through co-crystallization of hen egg white lysozyme (HEWL) as a model protein and Eu3+ complex as fluorescent