Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock
Fran Balamuth·Nathan Kuppermann·Elliot Long·Graham C. Thompson·Amanda Artis·Atzael B. Campos·Meredith L Borland·Stuart R. Dalziel·Adriana Yock‐Corrales·Ruchi Singh·Amanda Williams·Beata Mickiewicz·Christopher Hickey·Julie C. Fitzgerald·Benjamin L. Laskin·Robert W. Hickey·Michelle Eckerle·Waleed Alqurashi·Elizabeth Alpern·Lilliam Ambroggio·Mohamed Badawy·Shannon Baumer-Mouradian·Simon Berthelot·Lindsay D. Clukies·Simon Craig·Sarah Curtis·Adrienne L. Davis·Susan Duffy·Matthew A. Eisenberg·Jason G. Emsley·Ara Festekjian·Shane George·Rebecca Green·Karen E Gripp·Priya G. Jain·Shefali Jani·Gary Joubert·Pavan Judge·April Kam·Amit Kochar·Ioannis Koutroulis·Maria Y. Kwok·Roni D. Lane·Anna Lithgow·J. Lloyd·Karim Mansour·Julie K. McManemy·Claudia Morris·NJ Phillips·Arjun Rao·Alexander Rogers·Anupam Sehgal·Yasaman Shayan·Jonathan Silverman·Neil G. Uspal·Cheryl Vance·Emma Whyte·Jing Huang·Stephen B. Freedman·Franz E. Babl·Eunicia Tan·Scott L. Weiss
Among children treated for septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction when fluid resuscitation was administered with balanced fluid as compared with 0.9% saline. (Funded by Eunice Kennedy Shriver National Institute of Child Health and Human Development and others; PRoMPT BOLUS ClinicalTrials.gov number, NCT04102371.).