Olfactory radiomics signatures link pTau217 to cognitive impairment in probable Alzheimer’s disease: a multi-cohort machine learning study

Alzheimer's disease (AD) diagnosis remains challenging because current molecular biomarkers, though sensitive, lack spatial specificity. Radiomics offers a promising alternative by quantifying subtle microstructural alterations from routine MRI that are invisible to traditional volumetric analyses. Given that olfactory-related regions are preferentially affected in AD with olfactory dysfunction preceding cognitive decline, this study aimed to develop and validate radiomics signatures from these