Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export
X Wang·Xiao-Wei Chen·Lu Liu·Runze Huang·Yawei Wang·Bing Liu·Yifei Zhao·Yuangang Zhu·Jia Lv·Huimin Wang·L L Wu·Xinxuan Xu·Yaxin Li·Guanlin Wang·Y M Hu
Abstract The biogenesis and transport of lipoproteins are essential for systemic homeostasis and cardiometabolic health, yet how the secretory pathway acquires specialization to support high-capacity lipoprotein export remains unclear. Here, we report SEC16B as a tissue-selective modulator of the COPII machinery, critical for the efficient secretion of APOB-containing lipoproteins. Integrative bioinformatic analyses identify that SEC16B co-emerges with core genes involved in lipoprotein biogenes