Gemini Surfactant-Lipid-Based Nanovesicles (“GeminiSomes”) for Oral Delivery of Silybin: A Promising Strategy for Hepatoprotective Therapy
Gasper Fernandes·Srinivas Mutalik·Ruchira Raychaudhuri·Rahul Pokale·Raviraja N. Seetharam·Neha Kandpal·Naitik Jain
The rising global burden of hepatitis underscores the urgent need for effective liver-targeted therapies. Silybin, a natural flavonolignan from Silybum marianum, is well recognized for its hepatoprotective and antiviral potential but suffers from poor oral bioavailability due to low solubility and rapid metabolism. To address this, we developed a novel surfactant-based nanocarrier system to unlock the therapeutic potential of orally administered silybin. The optimized formulation, comprising bio