ChREBP-mediated regulation of lipid metabolism in liver and brown adipose tissue of long-lived mice
Mary Hager·Xinna Li·Leanne Mercier·Alexander Voorhees·Michael Lee·Lucas Ball·Jackson Yang·Andrzej Bartke·Richard A. Miller·Christopher Adam
De novo lipogenesis (DNL) is a metabolic process by which carbohydrates are converted into fatty acids and used for immediate energy or stored as triglycerides for later use. Increased DNL in brown adipose tissue (BAT) is believed to be a marker of metabolic health, but indicates poor metabolism if upregulated in hepatic tissue. ChREBP is a primary regulator of whole-body DNL and promotes production of key enzymes including fatty acid synthase, acetyl-CoA carboxylase, and stearoyl-CoA desaturase