Threshold labeled private set intersection protocol for human genetic testing

Abstract Recent breakthroughs in genome sequencing have revolutionized genetic diagnostics, yet secure sharing of sensitive genomic data remains a critical barrier to clinical collaboration.We address this challenge through Threshold Labeled Private Set Intersection (TLPSI), a novel cryptographic protocol without using computation-heavy homomorphic encryption. enabling confidential diagnostic label exchange between a client with private variants and a server hosting pathogenic variant databases–