The Severity and Characteristics of Pediatric Group A Streptococcal Meningitis in the Netherlands (2015–June 2024): Results From a Nationwide Multicenter Cohort Study
Mirte L Jansen·Mirjam van Veen·Adam J. Tulling·Nina M. van Sorge·Merijn Bijlsma·Emilie P. Buddingh’·E van Kempen
Background: From 2022 onwards, several countries, including the Netherlands, reported a marked increase in invasive group A streptococcal (iGAS) infections. Therefore, we aimed to describe the clinical presentation, disease course, treatment and outcomes of group A streptococcus (GAS) meningitis, a rare but severe manifestation of GAS infection in pediatric patients. Methods: Children with GAS meningitis were selected from the COPP-iGAS study, a national observational cohort study in children 0–