Abstract 412: Tanshinone analog induces ER stress mediated growth suppression via inhibition of MYC and E2F pathways in prostate cancer cells.

Abstract Prostate cancer (PCa) is the most common malignancy among men in developed countries, and its increasing incidence is closely associated with the rising prevalence of obesity and metabolic syndrome. Our previous studies demonstrated that the Tanshinone analog (TA) enhances ATF3 expression, inhibits adipogenesis and lipogenesis, and promotes adipocyte browning. Although both native Tanshinones and their analogs have been reported to influence PCa cell growth, the underlying mechanisms re