Clinicogenomic and Histopathologic Analyses of Supermassive Intrahepatic Cholangiocarcinoma and the Role of Ablative Radiotherapy
J. Abi Jaoude·Ethan B. Ludmir·Yinyin Yuan·Kristy K. Brock·Jean-Nicolas Vauthey·Ching-Wei D. Tzeng·Diana Shamsutdinova·Alexander J. Lazar·Deyali Chatterjee·Grace L. Smith·Prajnan Das·S. S. Lee·Hop S. Tran Cao·Milind Javle·Lawrence Kwong·Eugene J. Koay·Noah S. Meimoun·Brian De·Kaiping Liao·Ramez Kouzy·Humberto R. Nieves-Jiménez·Falk Poenisch·Peter Balter·Gabriel O. Sawakuchi·Emma B. Holliday·Bruce D. Minsky·Albert C. Koong·Alexandria Lau
Abstract Purpose: Ablative radiotherapy (RT) improves clinical outcomes in patients with unresectable intrahepatic cholangiocarcinoma (ICC). Applicability to “supermassive” ICC remains uncertain given smaller tumor diameters in previous studies. We hypothesize that supermassive ICCs are not mutationally or histopathologically different from nonsupermassive ICCs and so would respond favorably to ablative RT. Experimental Design: This is a retrospective study of patients with supermassive ICC trea