Time-Resolved Transcriptomic Profiling of Surgical Wounds Identifies Stage-Specific Therapeutic Targets for Residual Ovarian Cancer
Seongyun Lim·Yoo-Young Lee·Myeong-Seon Kim·Jin‐Oh Choi·Ji-Yoon Ryu·Jae Ryoung Hwang·Ju‐Yeon Choi·Mahesh Chandra Patra·Mohamed El-Agamy Farh·Insuk Sohn·Jeong-Won Lee·Young-Jae Cho
Background: The optimal timing of adjuvant chemotherapy after cytoreductive surgery in epithelial ovarian cancer remains uncertain, and perioperative wound-healing responses may transiently create a pro-tumorigenic and drug-resistant microenvironment. This study aimed to characterize time-dependent wound-induced transcriptomic alterations and to identify pharmacologic agents capable of reversing these responses. Methods: An ID8 murine ovarian cancer model was used to compare no treatment, anesth