Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

Translation failure, in which promising animal study results can not be reproduced in human trials, is a challenge in biomedical research. Metrics for replication success are widely used to evaluate reproducibility, i.e., the extent to which the results of a study agree with those of replication studies. The relevance of these metrics in assessing animal-to-human translation success (or faillure) is unclear. We conducted a simulation study to examine whether these metrics can quantify translatio