Angiography-Derived Fractional Flow Reserve to Guide PCI
William F. Fearon·Ajay J. Kirtane·Duzhi Zhao·Mahesh V. Madhavan·Ran Kornowski·Martin B. Leon·Allen Jeremias·Guy Witberg·Rasha Al-Lamee·David J. Cohen·Amir Kaki·Rahul P. Sharma·Robert W. Yeh·Alexandra Popma·M. Kim·Hiromasa Otake·Rajiv Tayal·H M Matsuo·Margaret McEntegart·Ankitkumar K. Patel·Yader Sandoval·Karim M. Al-Azizi·Kazuhiro Dan·Louai Razzouk·Stephane Fournier·Bjorn Redfors·Bassem M Chehab·Jeffrey J. Popma
Among patients with intermediate coronary-artery lesions undergoing physiological assessment in the cardiac catheterization laboratory, an angiography-guided strategy involving FFRangio was noninferior to a pressure-wire-guided strategy with respect to a composite end point of death, myocardial infarction, or unplanned clinically indicated coronary revascularization at 1 year. (Funded by CathWorks; ALL-RISE ClinicalTrials.gov number, NCT05893498.).