Hydroxyapatite nanoparticles synthesis with PAMAM-like dendrimers grown in situ on their surface for potential therapeutic use
Juan Pedro Ramirez-Pedroza·Juan Pedro Luna-Arias·Amir Ali·María Del Pilar Ramos-Godinez·Edgar Hernandez-Martinez·Sergio Armando Tomás-Velázquez
Abstract Hydroxyapatite nanoparticles are among the most promising materials, widely used to design novel platforms for treating diseases, including cancer, due to their biocompatibility and structure that enables a wide range of surface functionalization, as observed with polymers. In this work, we grew a polymeric structure, poly(amidoamine) (PAMAM-G4.0-like dendrimer), on the surface of nHAp. The resulting materials were characterized by transmission electron microscopy (TEM), Fourier-transfo