S267P mutation of OxyR regulator in Zymomonas mobilis: mechanism of oxidative stress tolerance and applications in cellulosic hydrolysate fermentation and oxidative stress monitoring

The peroxide-sensing transcriptional regulator OxyR plays a pivotal role in bacterial oxidative stress responses. The OxyR S267P mutation was previously identified in Zymomonas mobilis ZMNP, a mutant strain with enhanced hydrolysate tolerance. To investigate the biological function of revert strain and the corresponding mutant, phenotypic, transcriptomic, structural, and functional analyses were performed. The fermentation performance of strain ZMNPC in toxic xylose mother liquor had similar slo