Integration of transcriptomics and gut microbiomics reveals walnut septum polyphenols alleviate HFD-induced lipid disorders
Yuexiu Pan·Yang Tian·Jingjing Dai·Jun Sheng·Jing Xie·Min Su·Lei Peng·Jinlian Chen·Zi-Shan Hong·Xia Hu
Walnut septum, an underutilized agricultural by-product, exhibits anti-obesity potential. However, the in vivo hypolipidemic mechanisms of walnut septum polyphenols (WSP) remain unexplored. We investigated the effects of WSP on lipid metabolism in high-fat diet (HFD)-fed mice using integrated transcriptomic and gut microbiomic analyses. The results indicated that WSP inhibited lipid accumulation in HFD mice and ameliorated HFD-induced oxidative stress, inflammation, and gut barrier impairment. F