Determining the Activity of Imipenem/Relebactam Plus Aztreonam Against Constitutive Pseudomonas-Derived Cephalosporinase- and Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in a Hollow Fiber Infection Model
J Nicholas O’Donnell·Thomas P Lodise·Kelly Moolick·Avery I Nahorniak·Maxwell J Gifford·Katherine Young
Abstract Background Few treatment options exist for serious infections caused by metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa. This study evaluated imipenem/relebactam (I/R) plus aztreonam (ATM) against Pseudomonas-derived cephalosporinase (PDC)- and MBL-producing P. aeruginosa in a hollow fiber infection model, with ceftazidime/avibactam (CZA) plus ATM as a comparator. Methods Two isogenic PDC- and MBL-producing P. aeruginosa isolates (MB10480: IMP-1; MB10620: VIM-1) were studied