Alpha‐adrenergic mediated changes in blood pressure variability after hypoxia‐ischaemia in preterm fetal sheep
Simerdeep K. Dhillon·Laura Bennet·Victoria J. King·Masahiro Nakao·Olivia J. Lear·Chrisopher A. Lear·Benjamin A. Lear·Joanne O. Davidson·Alistair J. Gunn·Michael J. Beacom
Brain injury in preterm infants is common but often difficult to detect in the early stages. The present study investigated whether evolving preterm brain injury after exposure to hypoxia-ischaemia (HI) is associated with dynamic changes in arterial blood pressure variability (BPV) and tested the hypothesis that it was mediated by alpha-adrenoreceptor activity. Chronically instrumented 0.7 gestation fetal sheep received sham-HI (n = 8) or HI induced by 25 min of umbilical cord occlusion, followe