Modulation of the stress-activated proteins kinases Hog1/p38 and a TORC1-dependent kinase by curcumin is stress granule-dependent
Liuyi Zheng·Yuqi Wang·Marisa Penner·Natalie Samuell·Brianna Thomas·Dini Welivita·Jonathan S. Fisher·Zenae K. Cherry·Gabriela Soltys
Curcumin, a natural polyphenolic compound, is widely recognized for its anti-inflammatory, anti-cancer, and antimicrobial properties. Despite its long history of medicinal use, the precise mechanisms underlying its cellular effects remain incompletely understood. In yeast, curcumin has been shown to activate Hog1, a stress-activated protein kinase (SAPK), but the regulatory basis of this activation is unclear. Here, we investigated the role of stress granules in mediating the effects of curcumin