Divergent prefrontal activation between genders in depression during verbal fluency task: evidence from a large-scale fNIRS study

The findings revealed dissociable neural patterns of depression across sexes, moving beyond a uniform model of prefrontal hypoactivation. The neurological basis of depression in males may involve the right frontal eye field, while in females it may be linked to the left dorsolateral prefrontal cortex. The left dorsolateral prefrontal cortex appeared to be a key region for sex-specific brain alterations in depression.