A constitutive modelling framework for applications to in vivo longitudinal data: Evaluation in a 60‐day head‐down bed rest study on arterial function

Vascular cells continuously remodel the arterial wall (micro)structure in response to changes in their biomechanical/biochemical environment. Although the functional effects of arterial remodelling can be easily measured, assessing the underlying microstructural mechanisms is complex in vivo. Constitutive modelling is a computational technique that allows for linking whole-organ function to tissue constituent-level mechanics. However, the need for comprehensive biomechanical data for model param