Performance of a through-transmit aberration correction method for transcranial focused ultrasound: Simulation and experimental evaluation

Transcranial focused ultrasound is a promising neuromodulation tool, but skull-induced aberrations to the ultrasound beam require subject-specific correction. To predict and compensate for aberration, the standard in transcranial focused ultrasound is to perform acoustic simulations based on x-ray computed tomography images of the head. However, computed tomography-based methods face shortcomings due to imaging resolution and uncertainty in acoustic parameter estimates. Relativistic through-tran