Recent advances in drug discovery for Zika virus therapeutics
Rafael R.M. Souza·Milena B.P. Soares·Afrânio F. Evangelista·Danilo J.P.G. Rocha·Gabriel A.P. de Souza·Silvia I. Sardi·Gúbio Soares Campos·Brendo V.S. Macêdo·Carolina Melo Orrico-Ferreira
Zika virus (ZIKV) is a mosquito-borne Orthoflavivirus that became a major global health concern following the 2015-2016 outbreaks in South America, where infection was linked to severe neurological outcomes, including microcephaly, congenital Zika syndrome (CZS), and Guillain-Barré syndrome (GBS). Although substantial efforts are underway to develop effective preventive measures, including vaccines and vector-control strategies, ZIKV remains a priority pathogen under the World Health Organizatio