Bioprospection for Putative Antidiabetic Leads from Momordica balsamina Using Network Pharmacology, Molecular Modelling and Density Functional Theory Calculations

With the increasing incidence and mortality rate of type 2 diabetes mellitus (T2DM), alternative management options with better efficacy and less adverse effects are continuously being researched. Despite reports validating the antidiabetic property of Momordica balsamina, computational bioprospection for its putative antidiabetic leads and mechanism of action remain elusive. The study employed network pharmacology, molecular docking, molecular dynamics simulation, density functional theory, and