Hypothalamic Atrophy and Textural Changes in Polyglutamine Ataxias
Livia Rodrigues·Marcondes C. França·Alberto R. M. Martinez·Breno Kazuo Massuyama·José Luiz Pedroso·Orlando G. P. Barsottini·Juan Eugenio Iglesias·Simone Appenzeller·Letícia Rittner·Thiago J. R. Rezende
Background. Spinocerebellar ataxia (SCA) presents a complex genetic landscape, with over 40 subtypes. These autosomal dominant disorders manifest late onset and severe disability, primarily impacting the cerebellum but also involving other nervous system structures. While a single study has linked hypothalamic atrophy to SCA3, further research is needed to confirm and/or expand this association. This study aimed to investigate hypothalamic involvement in PolyQ SCAs, focusing on SCA 1, 2, 3, and