A spike-binding protein as a versatile tool to detect and inhibit transmissible gastroenteritis virus
Mantasha Khan·Quentin Nevers·Yannick Blanchard·Lionel Bigault·Maud Contrant·Philippe Minard·Fanny Boursin·Nicolas Aubrey·Juliette Jacquelin·Nicolas Meunier·Marie Valerio-Lepiniec·Bernard Delmas·Nathalie Lejal·Agathe Urvoas
The Spike protein of coronaviruses (CoVs) plays an essential role in viral entry and is the main target of antibodies produced following vaccination or natural infection. Most of the knowledge on the function of Spike proteins is incoming from the beta-CoV genus causing severe diseases in humans. Indeed, numerous tools such as pseudoviruses have been developed to measure beta-CoV Spikes activity simply and rapidly, and several ligands of different natures binding to these Spike proteins (such as