Miniaturized fiber-coupled microscope with cell-embedded hydrogel for odorant sensing

Cell-based biosensors employing olfactory receptor (OR)-expressing cells can detect odorant molecules with high selectivity and sensitivity; however, their translation into portable platforms remains limited by bulky optical systems and fixed configurations. Here, we present a compact and reconfigurable odorant sensing platform that integrates a miniature fluorescence microscope (MFM) with a fan-out optical fiber array to decouple the sensing site from the optical module. Each fiber tip is conne