In this study, we have newly identified the potential value of microRNA-27b-5p and microRNA-497-5p as actionable biomarkers of the profibrotic response to IL-11 in the heart. Future studies should validate the translational potential of the microRNAs as new clinical biomarkers and therapeutic targets.
Interleukin 11–Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis
Roman Tikhomirov·Julia Gorelik·Zoe Kwan·Carla Lucarelli·Simona Greco·Chi Him Kendrick Yiu·Mark Sweeney·Catherine Mansfield·Santiago Nicolas Piella·Julia Dielesen·Prashant K. Srivastava·Maddalena Tessari·Giuseppe Faggian·Joseph Okafor·Giovanni Battista Luciani·Maryam Anwar·Veronika Boichenko·Victoria Maria Noakes·Costanza Emanueli·P Leszek·Diana Kazharova·Mathilde Labbé·Fabio Martelli·Lorenzo Menicanti·Benedict Reilly O’Donnell·Germana Zaccagnini