ABSTRACT This study presents a sophisticated sensor based on microwave resonators employing complementary split ring resonators (CSRRs), engineered with uneven coupling and a unique spatial configuration to attain high sensitivity in the detection and characterization of bio‐fluids. The suggested sensor focuses on medical diagnostic applications, such as blood glucose monitoring and evaluation of electrolyte balance. The core, unevenly coupled CSRR‐loaded resonator sensor is developed using CST