Mitochondria are organelles whose function and dynamics, that is fission, fusion, transport and selective removal (mitophagy), are fundamental for eukaryotic cells. Their dysfunction is associated with age-related neurodegeneration and the aging immune system. MitoNEET, an iron-sulfur (Fe-S) cluster-containing protein localised at the outer membrane of mitochondria, has emerged as a key regulator of mitochondrial respiration and linked to fission, fusion, and mitophagy. In this perspective artic