HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no murine models that specifically target tissue T cells while leaving their lymphoid counterparts untouched. Here, we leverage the observation that during influenza infection, HIF-1α regulatory activity is higher in the lung compared with lymph node CD4⁺ T cells. Inducible deletion of Hif1a in CD4⁺ T cells, at the onset of its act