Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated Na+ and K+ currents

Olfactory sensory neurons (OSNs) detect odorants and send electrical signals to glomeruli in the olfactory bulb. Unlike most neurons, OSNs are continuously regenerated throughout life and immature neurons contribute to odorant-evoked responses in glomeruli. However, their intrinsic excitability properties are largely unknown. Here, we used acute slices of the olfactory epithelium from neonatal OMP-GFP mice to visually identify mature and immature OSNs and performed patch-clamp recordings to inve