Pharmacogenomic predictors of anthracycline-induced cardiotoxicity in breast cancer patients: a systematic review and meta-analysis
Vani Mahathi Bulusu·Murali Munisamy·Suruchi Jain·Akansha Choudhary·Jitendra Kumar Singh·Rupinder Kaur Kanwar·Bhushan Shah·Karthik S. Udupa·Amit Kumar·Neha Arya·Sheela Sawant·Saikat Das·Surulivel Rajan Mallayasamy
Anthracyclines significantly improve overall survival and play a vital role in the treatment of breast cancer. However, they are associated with cardiac dysfunction, which is often irreversible. Although anthracycline-induced cardiotoxicity (AIC) is dose-dependent, the difference in susceptibility patterns suggests the role of pharmacogenomics. Several studies explored the role of genetic variants in AIC. Integrating pharmacogenomic testing with routine anthracycline surveillance will help to pr