Preliminary evidence of extrarenal sodium storage in a large mammal: implications for comparative physiology and hypertension research

Under conditions of dietary sodium (Na+) excess, the kidneys may fail to adequately excrete Na+, potentially compromising blood pressure homeostasis. Body tissues, such as skin, can offer sites of short-term extrarenal Na+ storage and previous research has shown that this can help guard against hypertension in small mammals (e.g., rodents). Large mammals have relatively greater Na+ storage potential, but whether extrarenal Na+ storage occurs for this group is unknown. Here, we report preliminary