A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria
D. Herbert Opi·James G. Beeson·Jessica Brewster·Wines Bd·Kael L. Schoffer·Tim Spelman·Rhea J. Longley·Mark Hogarth·Matthias Harbers·Benson Kiniboro·Peter Siba·Ivo Mueller·Takafumi Tsuboi·Leanne J. Robinson·Yanie Tayipto·Eizo Takashima·Linda Reiling
Plasmodium vivax is the most widespread cause of malaria with a high burden of disease. Progress in reducing the global malaria burden has stalled with no vaccines available partly due to a limited knowledge of targets and mechanisms of protective immunity. We developed a platform to quantify antibody functions to multiple P. vivax antigens and dissect immunity in a longitudinal cohort of children from Papua New Guinea at risk of P. vivax malaria. We identified antigens targeted by multiple func